Source: https://guthlabs.ai/docs/instrument-workflows/buffer-bench/

instrument chain / verified-workflow-definition

# Buffer Bench

Design a buffer at target pH and physically mix it.

Status: **observed**Lifecycle: **verified-workflow-definition**

## Goal

Design a buffer at target pH and physically mix it.

## Instrument chain

- 01

**[Ka/Kb ⇄ pKa/pKb Converter](<https://guthlabs.ai/docs/instruments/ka-kb-pka-pkb-converter/>)**

constants

VERIFIED

- 02

**[Henderson–Hasselbalch Buffer Calculator](<https://guthlabs.ai/docs/instruments/henderson-hasselbalch-buffer-calculator/>)**

ratio for pH

VERIFIED

- 03

**[Buffer Preparation Calculator](<https://guthlabs.ai/docs/instruments/buffer-preparation-calculator/>)**

moles & masses

VERIFIED

- 04

**[Buffer Capacity Estimator](<https://guthlabs.ai/docs/instruments/buffer-capacity-estimator/>)**

is it strong enough

VERIFIED

- 05

**[Molarity / Solution Prep Calculator](<https://guthlabs.ai/docs/instruments/molarity-solution-prep-calculator/>)**

stock prep

VERIFIED

- 06

**[Dilution Calculator (C1V1=C2V2)](<https://guthlabs.ai/docs/instruments/dilution-calculator-c1v1-c2v2/>)**

dilutions

VERIFIED

- 07

**[Serial Dilution Calculator](<https://guthlabs.ai/docs/instruments/serial-dilution-calculator/>)**

ladders

VERIFIED

- 08

**[Titration Equivalence-Point Calculator](<https://guthlabs.ai/docs/instruments/titration-equivalence-point-calculator/>)**

verification titration

VERIFIED

## Handoffs and cross-checks

pKa → ratio → masses → capacity check; titration closes the loop experimentally.

## PointGuard stance

After computing masses, back-substitute into Henderson-Hasselbalch to confirm the target pH is reproduced (the t4-063 failure mode).

## Sources and evidence

These pointers bind the page to evidence. They do not grant authority or collapse verification into deployment.

- `INSTRUMENT_COMBOS.json`

- `VERIFIED_LEDGER.json`