Source: https://guthlabs.ai/docs/instrument-workflows/renal-dosing/

instrument chain / verified-workflow-definition

# Renal Dosing Chain (education)

Labs → clearance → dose → infusion, with dual eGFR agreement.

Status: **observed**Lifecycle: **verified-workflow-definition**

## Goal

Labs → clearance → dose → infusion, with dual eGFR agreement.

## Instrument chain

- 01

**[Creatinine Clearance (Cockcroft-Gault)](<https://guthlabs.ai/docs/instruments/creatinine-clearance-cockcroft-gault/>)**

CrCl

VERIFIED

- 02

**[eGFR (CKD-EPI 2021, race-free)](<https://guthlabs.ai/docs/instruments/egfr-ckd-epi-2021-race-free/>)**

primary eGFR

VERIFIED

- 03

**[eGFR (MDRD, legacy)](<https://guthlabs.ai/docs/instruments/egfr-mdrd-legacy/>)**

cross-check eGFR

VERIFIED

- 04

**[Weight-Based Dosage Calculator (education)](<https://guthlabs.ai/docs/instruments/weight-based-dosage-calculator-education/>)**

mg/kg dosing

VERIFIED

- 05

**[Loading & Maintenance Dose Calculator](<https://guthlabs.ai/docs/instruments/loading-maintenance-dose-calculator/>)**

PK dosing

VERIFIED

- 06

**[IV Drip Rate Calculator](<https://guthlabs.ai/docs/instruments/iv-drip-rate-calculator/>)**

administration

VERIFIED

- 07

**[Anion Gap Calculator](<https://guthlabs.ai/docs/instruments/anion-gap-calculator/>)**

labs context

VERIFIED

- 08

**[Osmolarity / Tonicity Calculator](<https://guthlabs.ai/docs/instruments/osmolarity-tonicity-calculator/>)**

labs context

VERIFIED

## Handoffs and cross-checks

CrCl/eGFR gates dosing decisions; dose → volume → gtt/min.

## PointGuard stance

Educational only, never individualized advice; run CKD-EPI and MDRD together and flag stage-boundary disagreement.

## Sources and evidence

These pointers bind the page to evidence. They do not grant authority or collapse verification into deployment.

- `INSTRUMENT_COMBOS.json`

- `VERIFIED_LEDGER.json`