Source: https://guthlabs.ai/docs/instruments/homa-ir-insulin-resistance-index-education/mechanism/

instrument mechanism / verified-clean

# HOMA-IR Insulin Resistance Index (education) mechanism

The inspectable method record for HOMA-IR Insulin Resistance Index (education), kept separate from implementation and qualification.

Status: **VERIFIED_CLEAN**Lifecycle: **verified-clean**

## Model scope

The formula is the standard conventional HOMA-IR formula for fasting glucose in mg/dL and fasting insulin in µU/mL. The honest-label text is appropriate, but the specification needs explicit, enforceable input units and a defined fasting condition before it can receive PASS.

No additional formula finding is recorded.

## Units and conventions

- Fasting glucose must be supplied in mg/dL.

- Fasting insulin must be supplied in µU/mL (numerically equivalent to µIU/mL).

- The divisor 405 is the conventional approximation for glucose in mg/dL and insulin in µU/mL; if glucose is in mmol/L, use the equivalent divisor 22.5 or convert glucose to mg/dL first.

- Both measurements are assumed to be obtained under fasting conditions, but the required fasting duration is not specified or enforceable by the input schema.

## Inspectable vector

One of 4 source-bound review vectors:

````
{
  "inputs": {
    "fasting_glucose_mg_dL": 90,
    "fasting_insulin_uU_mL": 10
  },
  "expected_outputs": {
    "homa_ir": 2.2222222222
  },
  "working": "HOMA-IR = (90 × 10) / 405\n= 900 / 405\n= 20 / 9\n= 2.2222222222"
}
````

## Failure boundary

**BREAK_CLAIMED** · SELF_FLAGGED

Finite JavaScript inputs of 1e308 for both variables overflow during multiplication and produce Infinity rather than a finite HOMA-IR value. The specification also provides no stated validation for physiologically impossible zero or negative measurements and no unit-conversion guard beyond naming mg/dL.

## Other records

[01**Overview**](<https://guthlabs.ai/docs/instruments/homa-ir-insulin-resistance-index-education/>)[03**Implementation**](<https://guthlabs.ai/docs/instruments/homa-ir-insulin-resistance-index-education/implementation/>)[04**Qualification**](<https://guthlabs.ai/docs/instruments/homa-ir-insulin-resistance-index-education/qualification/>)

## Sources and evidence

These pointers bind the page to evidence. They do not grant authority or collapse verification into deployment.

- `VERIFIED_LEDGER.json`

- `evidence-tranche5/tranche5-results.json`

- `BOUNDARY_HAZARD_CATALOG.json`