Source: https://guthlabs.ai/docs/instruments/loading-maintenance-dose-calculator/

instrument / verified-clean

# Loading & Maintenance Dose Calculator

The current ledger marks this instrument verified clean within the source-bound verification corpus.

Status: **VERIFIED_CLEAN**Lifecycle: **verified-clean**

## Inspectable records

[01**Overview**Purpose and lifecycle](<https://guthlabs.ai/docs/instruments/loading-maintenance-dose-calculator/>)[02**Mechanism**Method and assumptions](<https://guthlabs.ai/docs/instruments/loading-maintenance-dose-calculator/mechanism/>)[03**Implementation**Binding and validation](<https://guthlabs.ai/docs/instruments/loading-maintenance-dose-calculator/implementation/>)[04**Qualification**Evidence and errata](<https://guthlabs.ai/docs/instruments/loading-maintenance-dose-calculator/qualification/>)

## Ledger state

The current ledger marks this instrument verified clean within the source-bound verification corpus.

**Area**: Biology, Medicine & Pharmacology (educational estimates only — every panel labeled not-medical-advice)

**Tranche**: tranche-4

**Evidence ID**: t4-062

**Ledger rows**: 1

No ledger note is attached.

## Review findings

The formulas are valid simplified pharmacokinetic formulas under consistent units, first-order linear kinetics, and F = 1. The specification needs an explicit distinction between maintenance dose per interval and maintenance rate, plus an explicit bioavailability assumption and target-concentration definition. The existing educational-only, not-medical-advice label is appropriate but does not resolve these ambiguities.

### Formula and scope findings

- MD = target concentration × clearance × dosing interval is the standard maintenance dose per dosing interval, not a maintenance rate; the maintenance rate would be target concentration × clearance. The output label 'maintenance dose/rate' is ambiguous.

- Both formulas implicitly assume bioavailability F = 1. If oral, extravascular, or otherwise incomplete administration is supported, the standard formulas require division by F: LD = Cp,target × Vd / F and maintenance dose = Cp,target × CL × τ / F.

- The loading-dose formula assumes the target concentration is the concentration to be achieved immediately and that the relevant volume of distribution is known; the target may need to be distinguished as target steady-state average, peak, or trough concentration.

### Unit assumptions

- Target concentration must use concentration units compatible with clearance and volume of distribution; for example, mg/L with Vd in L and CL in L/h.

- Vd must be in volume units and clearance in volume-per-time units.

- Dosing interval τ must be in the same time unit used in clearance; with CL in L/h, τ must be in hours.

- With mg/L, L, and hours, loading dose and maintenance dose are in mg, and maintenance rate is in mg/h.

- The calculations assume F = 1, no dose rounding, and no unit conversion beyond explicitly supplied inputs.

## Boundary hardening

**BREAK_CLAIMED** · SELF_FLAGGED

The extreme-magnitude vector produces Infinity for both outputs under plain JavaScript arithmetic. The instrument should reject non-finite inputs or outputs rather than display Infinity as a usable educational dose. The specification also contains no actual formula branch, so an implementation inventing a threshold-based branch would be unsupported.

## Errata and corrections

No applied erratum is attached to this unique-name record.

## Inspectable example

4 review vectors are recorded. One source-bound sample is shown below.

````
{
  "inputs": {
    "target_concentration": "10 mg/L",
    "Vd": "35 L",
    "clearance": "4.2 L/h",
    "dosing_interval": "12 h"
  },
  "expected_outputs": {
    "loading_dose": "350 mg",
    "maintenance_dose_per_interval": "504 mg",
    "maintenance_rate": "42 mg/h"
  },
  "working": "Loading dose = 10 mg/L × 35 L = 350 mg. Maintenance dose = 10 mg/L × 4.2 L/h × 12 h = 42 mg/h × 12 h = 504 mg. Maintenance rate = 10 mg/L × 4.2 L/h = 42 mg/h."
}
````

## Related workflows

[Renal Dosing Chain (education)PK dosing](<https://guthlabs.ai/docs/instrument-workflows/renal-dosing/>)

## Sources and evidence

These pointers bind the page to evidence. They do not grant authority or collapse verification into deployment.

- `VERIFIED_LEDGER.json · VERIFIED_CLEAN`

- `evidence-tranche4/tranche4-results.json`

- `BOUNDARY_HAZARD_CATALOG.json`